Study of clinical, laboratory, and upper gastrointestinal endoscopic profile in patients of alcoholic liver disease in Sikkim
Study of clinical, laboratory, and upper gastrointestinal endoscopic profile in patients of alcoholic liver disease in Sikkim
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Background: Alcoholic liver disease (ALD) is the most common liver disease in India, caused by excessive intake of alcohol even though being a preventable disease.The three principal types of ALD are fatty liver, alcoholic hepatitis, and cirrhosis.Objectives: Study of clinical presentation, laboratory parameters, abdominal sonographic and upper gastrointestinal endoscopic findings, and complications in patients of ALD in Sikkim.Methods: Descriptive observational hospital-based study was carried on 100 ALD patients admitted in Department of General Medicine in a teaching hospital of Sikkim, who fulfilled the inclusion criteria.Data were tabulated and analyzed using IBM-SPSS statistics version 22 software.
Results: The mean age was 48 years with majority being males (84%), occupied here in unskilled work (67%), with lower education level (52%), and belonging to middle socioeconomic status (56%).The average intake of alcohol by males was 63 g/day, and in females, it was 40 g/day with average duration of alcohol intake being 16 years.Most common presenting features were nausea (90%), jaundice (67%), and anorexia (64%).The mean total bilirubin (mg/dL), aspartate aminotransferase (IU/L), alanine aminotransferase (IU/L), serum albumin (g/dL), and prothrombin time difference (seconds) were 4.74, 110.
2, 59.1, 3.4, and 4.1.Abdominal sonography revealed ascites (53%) and cirrhosis (43%), and upper gastrointestinal endoscopy revealed varices (52%) as common finding.
The most common complications were gastrointestinal bleeding (54%) and portal hypertension (51%).Conclusions: Due to high mortality and morbidity associated with this preventable liver disease along with a multidisciplinary approach to tackle this alcohol menace, a sound regional knowledge of clinical presentation and workup findings can help in effective treatment Canvas Mesh Athletic Running Shoes strategies of the same.